Subventricular Zone Cell Migration: Lessons from Quantitative Two-Photon Microscopy
نویسندگان
چکیده
منابع مشابه
Subventricular Zone Cell Migration: Lessons from Quantitative Two-Photon Microscopy
Neuroblasts born in the adult subventricular zone (SVZ) migrate long distances in the rostral migratory stream (RMS) to the olfactory bulbs where they integrate into circuitry as functional interneurons. As very little was known about the dynamic parameters of SVZ neuroblast migration, we used two-photon time-lapse microscopy to analyze migration in acute slices. This involved analyzing 3D stac...
متن کاملCell migration in the postnatal subventricular zone
New neurons are constantly added to the olfactory bulb of rodents from birth to adulthood. This accretion is not only dependent on sustained neurogenesis, but also on the migration of neuroblasts and immature neurons from the cortical and striatal subventricular zone (SVZ) to the olfactory bulb. Migration along this long tangential pathway, known as the rostral migratory stream (RMS), is in man...
متن کاملCell migration in the postnatal subventricular zone.
New neurons are constantly added to the olfactory bulb of rodents from birth to adulthood. This accretion is not only dependent on sustained neurogenesis, but also on the migration of neuroblasts and immature neurons from the cortical and striatal subventricular zone (SVZ) to the olfactory bulb. Migration along this long tangential pathway, known as the rostral migratory stream (RMS), is in man...
متن کاملInvolvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke.
After brain injury, neuroblast cells from the subventricular zone (SVZ) expand and migrate toward damaged tissue. The mechanisms that mediate these neurogenic and migratory responses remain to be fully dissected. Here, we show that bromodeoxyuridine-labeled and doublecortin-positive cells from the SVZ colocalize with the extracellular protease matrix metalloproteinase-9 (MMP-9) during the 2 wee...
متن کاملCellular and molecular determinants of stroke-induced changes in subventricular zone cell migration.
A remarkable aspect of adult neurogenesis is that the tight regulation of subventricular zone (SVZ) neuroblast migration is altered after ischemic stroke and newborn neurons emigrate towards the injury. This phenomenon is an essential component of endogenous repair and also serves to illuminate normal mechanisms and rules that govern SVZ migration. Stroke causes inflammation that leads to cytok...
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ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2011
ISSN: 1662-4548
DOI: 10.3389/fnins.2011.00030